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[Refractive development and form-deprivation induced myopic refractive error in CBA/CaJ mice.] [Article in Chinese]

LI Yun-Yun, QIAN Kang-Wei, WU Xiao-Hua, ZHOU Wei, ZHONG Yong-Mei^*, WENG Shi-Jun^*

Institute of Neurobiology, Institutes of Brain Science, State Key Laboratory of Medical Neurobiology and Collaborative Innovation Center for Brain Science, Fudan University, Shanghai 200032, China

Abstract

Due to the advantages in genetic manipulation, mice have become one of the most commonly used mammalian models for the study of mechanisms underlying myopia development. However, the vast majority of laboratory mouse strains are incapable of synthesizing melatonin, a neurohormone that may play an important role in myopia generation in humans. The present study investigated refractive development profiles in the CBA/CaJ mouse, a strain proficient in melatonin, and determined whether and how its refractive development could be affected by form-deprivation. Eccentric infrared photoretinoscopy revealed that this animal could be stably refracted, and the refractive error underwent developmental changes, which increased with age in the hyperopic direction and eventually got stable approximately 9 weeks after birth. The absolute values of refractive error in CBA/CaJ mice were larger than those of age-matched C57BL/6 mice, whereas the time points when refractive error reached steady state were similar between the two strains. Five weeks of form-deprivation applied to 3-week-old CBA/CaJ mice by translucent occluder wear caused a significant myopic shift in refractive error, indicating that this strain could be adequately used as a myopia model.

Key words: myopia; melatonin; form-deprivation; refractive error; CBA mouse

Received: 2016-01-03　　Accepted: 2016-01-29

Corresponding author: 钟咏梅,翁史钧　　E-mail: ymzhong@fudan.edu.cn, sjweng@fudan.edu.cn

Citing This Article：

LI Yun-Yun, QIAN Kang-Wei, WU Xiao-Hua, ZHOU Wei, ZHONG Yong-Mei, WENG Shi-Jun. [Refractive development and form-deprivation induced myopic refractive error in CBA/CaJ mice.] [Article in Chinese]. Acta Physiol Sin 2016; 68 (2): 135-140 (in Chinese with English abstract).