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Relationships of glucose transporter 4 with cognitive changes induced by high fat diet and glucose metabolism in hippocampus

ZHANG Yun-Li^*, WANG Lin

1Shanghai Key Laboratory of Human Sport Competence Development and Maintenance, School of Sport Science, Shanghai University of Sport, Shanghai 200438, China； 2Theory Teaching and Research Section, Department of Physical Education, Liaocheng University,Liaocheng 252059, China

Abstract

The hippocampus not only plays a role in appetite and energy balance, but also is particularly important in learning andmemory. Figuring out the relationships of hippocampal glucose transporter 4 (GLUT4) with hippocampal glucose metabolism and
hippocampus-dependent cognitive function is very important to clearly understand the pathophysiological basis of nutritional obesity and diabetes-related diseases, and treat obesity and cognitive dysfunction. Therefore, this study reviewed recent researches conducted on hippocampal GLUT4, hippocampal glucose metabolism, and hippocampus-dependent cognitive function. In this review, we mainly discussed: (1) The structure of GLUT4 and the distribution and function of GLUT4 in the hippocampus; (2) The translocation of GLUT4 in the hippocampus; (3) The relationships of the PI3K-Akt-GLUT4 signaling pathway with the high fat diet-induced changes of cognitive function and the glucose metabolism in the hippocampus; (4) The associations of the PI3K-Akt-GLUT4 signaling pathway with the diabetes-related cognitive dysfunction in the hippocampus; (5) The potential mechanisms of cognitive dysfunction induced
by glucose metabolic disorder.

Key words: glucose transporter 4; hippocampus; glucose metabolism; learning and memory

Received: 　　Accepted:

Corresponding author: 张云丽　　E-mail: zhangyunli@lcu.edu.cn

Citing This Article：

ZHANG Yun-Li, WANG Lin. Relationships of glucose transporter 4 with cognitive changes induced by high fat diet and glucose metabolism in hippocampus. Acta Physiol Sin 2016; 68 (3): 335-342 (in Chinese with English abstract).