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P2X7 receptor and inflammatory bowel disease

MENG Shuang-Ping, MA Bei^*

Experimental Training Center for Basic Medical Sciences, The Second Military Medical University, Shanghai 200433, China

Abstract

P2X7 receptors are closely associated with inflammation, and they have been found to be expressed on colonic cells broadly.In animal model of colonic inflammation, ATP/P2X7 signaling mainly promotes inflammation, and a variety of cells, including macrophages, dendritic cells, T cells, mast cells and enteric neurons are involved in this process. However, in the toxoplasmic ileitis, P2X7 signaling plays a role in inhibiting the inflammation. But, the underlying mechanisms are still not clear. This review outlined the research progresses of P2X7 receptors in inflammatory bowel disease (IBD) to provide some clues for the further studies on the relationship
between P2X7 receptors and IBD.

Key words: inflammatory bowel disease; cytokines; ATP; P2X7 receptor; purinergic signaling

Received: 2016-02-23　　Accepted: 2016-04-23

Corresponding author: 马蓓　　E-mail: mmbb98@sohu.com

Citing This Article：

MENG Shuang-Ping, MA Bei. P2X7 receptor and inflammatory bowel disease. Acta Physiol Sin 2016; 68 (3): 343-351 (in Chinese with English abstract).