Issue Archive

[Regulation of miR-24 on vascular endothelial cell function and its role in the development of cardiovascular disease.] [Article in Chinese]

CHEN Wei, OU He-Sheng^*

College of Pharmacy, Guangxi Medical University, Nanning 530021, China

Abstract

microRNA-24 (miR-24) belongs to miR-23~27~24 cluster. It is highly expressed in vascular endothelial cells (VECs), and plays an important role in the regulation of VECs specific gene expression. Recent studies indicate that miR-24 is involved in the regulation of VECs function such as proliferation, apoptosis, angiopoiesis, inflammation, and differentiation. The dysregulation of miR-24 is associated with dysfunction or even damage of VECs, and contributes to the development of cardiovascular disease. In this review, we summarized the molecular mechanisms of miR-24 in regulating VECs function, and its role and importance during the development of cardiovascular disease.

Key words: Vascular endothelial cell; miR-24; VECs function; cardiovascular disease

Received: 2015-12-04　　Accepted: 2016-03-09

Corresponding author: 欧和生　　E-mail: hsou01@yahoo.com

Citing This Article：

CHEN Wei, OU He-Sheng. [Regulation of miR-24 on vascular endothelial cell function and its role in the development of cardiovascular disease.] [Article in Chinese]. Acta Physiol Sin 2016; 68 (2): 201-206 (in Chinese with English abstract).