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[Mechanism of cardiac atrophy under weightlessness/simulated weightlessness.] [Article in Chinese]

ZHONG Guo-Hui, LING Shu-Kuan, LI Ying-Xian^*

State Key Lab of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, Beijing 100094, China

Abstract

Cardiac remodeling is the heart’s response to external or internal stimuli. Weightlessness/simulated weightlessness leads to cardiac atrophy and heart function declining. Understanding the mechanism of cardiac atrophy under weightlessness is important to help astronaut recover from unloading-induced cardiovascular changes after spaceflight. Unloading-induced changes of hemodynamics, metabolic demands and neurohumoral regulation contribute to cardiac atrophy and function declining. During this process, Ca2+-related signaling, NF-κB signaling, ERK signaling, ubiquitin-proteasome pathway and autophagy are involved in weightlessness-induced cardiac atrophy. This article reviews the underlying mechanism of cardiac atrophy under weightlessness/simulated weightlessness.

Key words: weightlessness/simulated weightlessness; cardiac atrophy; physiological mechanism; molecular mechanism

Received: 2015-10-12　　Accepted: 2015-12-09

Corresponding author: 李英贤　　E-mail: yingxianli@aliyun.com

Citing This Article：

ZHONG Guo-Hui, LING Shu-Kuan, LI Ying-Xian. [Mechanism of cardiac atrophy under weightlessness/simulated weightlessness.] [Article in Chinese]. Acta Physiol Sin 2016; 68 (2): 194-200 (in Chinese with English abstract).