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Structure and function of the adapter protein Gab and its role in the development of tumor, inflammation and cardiovascular diseases

LI An-Yi； GUO Xiao-Xi, LIU Ying, YANG Yang, XU Tian-Rui, AN Shu^*

Cell Signal Transduction Laboratory, Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China

Abstract

Gab proteins, Grb2 (growth factor receptor binding protein 2)-associated binder, are important scaffolding adapter proteins required by many signaling pathways. In mammals, the Gab proteins mainly consist of Gab1, Gab2 and Gab3, and are involved in the amplification and integration of signal transduction evoked by a variety of extracellular stimuli, including various growth factors and cytokines. They are known to play key roles in many biological processes through the two classical signal pathways, SHP2/RAS/ERK and PI3K/AKT. In this review, we provide an overview of the structure and function of the scaffolding adapter, Gab, with a special focus on its role in tumor, inflammation and cardiovascular diseases.

Key words: Gab proteins; tumor ; inflammation ; cardiovascular diseases

Received: 2015-10-12　　Accepted: 2015-12-08

Corresponding author: 徐天瑞,安输　　E-mail: xtrgfq@hotmail.com, aslxj@mail.ustc.edu.cn

Citing This Article：

LI An-Yi； GUO Xiao-Xi, LIU Ying, YANG Yang, XU Tian-Rui, AN Shu. Structure and function of the adapter protein Gab and its role in the development of tumor, inflammation and cardiovascular diseases. Acta Physiol Sin 2016; 68 (1): 57-64 (in Chinese with English abstract).