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[Alteration of neural oscillations in hippocampal CA3 area in the fast avoidance response rat before and after electric shock avoidance training.] [Article in Chinese]

WANG Wei-Wei, WANG Dan-Dan, WANG Dan, GUAN Yan, TANG Ying-Ying, YE Zheng, LI Jing, LI Min, ZHU Zai-Man, PAN Qun-Wan

Clinical Medical College； Department of Physiology, Wannan Medical College, Wuhu 241002, China

Abstract

The purpose of the present study is to explore the relationship of spatial learning ability and specific electrical activities of neural oscillations in the rat. The fast and general avoidance response groups were selected on the basis of the animals’ responses to the electric shock in Y type maze, and their local field potentials (LFPs) of hippocampal CA3 area were recorded by wireless telemetry before and after shock avoidance training, respectively. The components of neural oscillations related to spatial identifying and learning ability were analyzed. The results showed that, compared with the general avoidance response group, the fast avoidance
response group did not show any differences of LFPs in hippocampal CA3 area before electric shock avoidance trial, but showed
significantly increased percentages of 0–10 Hz and 30–40 Hz rhythm in right hippocampal CA3 area after the shock avoidance training (P < 0.01 or P < 0.05). Fast Fourier transform showed that percentage increase of 0–10 Hz band occurred mainly in θ (3–7 Hz) frequency, and 30–40 Hz frequency change was equivalent to the γ1 band. Furthermore, compared with those before training, only the percentages of β, β2 (20–30 Hz) and γ1 rhythm increased (P < 0.01 or P < 0.05) in fast avoidance response rats after training, while the θ rhythm percentage remained unchanged. In contrast, θ rhythm percentage and the large amplitude (intensity: +2.5 – −2.5 db) θ waves in right CA3 area of general avoidance response rats were significantly reduced after training (P < 0.01). These results suggest that the increased percentages of β2 and γ1 rhythm and high-level (unchanged) percentage of θ rhythm in the right hippocampus CA3 area might be related to strong spatial cognition ability of fast avoidance response rats.

Key words: electric shock avoidance training; hippocampus CA3 region; local field potential; neural oscillations

Received: 2015-03-30　　Accepted: 2015-08-03

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Citing This Article：

WANG Wei-Wei, WANG Dan-Dan, GUAN Yan, TANG Ying-Ying, YE Zheng, LI Jing, LI Min, ZHU Zai-Man, PAN Qun-Wan. [Alteration of neural oscillations in hippocampal CA3 area in the fast avoidance response rat before and after electric shock avoidance training.] [Article in Chinese]. Acta Physiol Sin 2015; 67 (5): 487-496 (in Chinese with English abstract).