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CREB-regulated transcription coactivator 1: important roles in neurodegenerative disorders

XUE Zhan-Cheng, WANG Chuang, WANG Qin-Wen, ZHANG Jun-Fang

School of Medicine, Ningbo University, Ningbo 315211, China； Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo 315211, China

Abstract

The cAMP-responsive element binding protein (CREB)-regulated transcription coactivator, CRTC (also known as transducer of regulated CREB, TORC), is identified as a potent modulator of cAMP response element (CRE)-driven gene transcription. The CRTC family consists of three members (CRTC1–3), among which the CRTC1 shows the highest expression in the brain. Several studies have demonstrated that the CRTC1 plays critical roles in neuronal dendritic growth, long-term synaptic plasticity, memory consolidation and reconsolidation etc., whereas dysfunction of CRTC1 is mainly involved in neurodegenerative disorders. In light of these findings, we aim to review recent research reports that indicate the CRTC1 dysfunction and its underlying mechanisms in the neurodegenerative disorders.

Key words: CREB-regulated transcription coactivator 1; cAMP-responsive element binding protein; CRE-driven gene transcription; neurodegenerative disorders; Alzheimer’s disease; Huntington’s disease

Received: 2014-12-23　　Accepted: 2015-02-26

Corresponding author: 张俊芳　　E-mail: zhangjunfang@nbu.edu.cn

Citing This Article：

XUE Zhan-Cheng, WANG Chuang, WANG Qin-Wen, ZHANG Jun-Fang. CREB-regulated transcription coactivator 1: important roles in neurodegenerative disorders. Acta Physiol Sin 2015; 67 (2): 155-162 (in Chinese with English abstract).