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[Anti-gastric cancer effect of melatonin and Bcl-2, Bax, p21 and p53 expression changes.] [Article in Chinese]

XU Li, JIN Qing-Dong, GONG Xi, LIU Hui, ZHOU Rui-Xiang

Department of Physiology, Basic Medical College of Putian University, Putian 351100, China； Department of Human Anatomy and Histology and Embryology, Neurobiology Research Center, Fujian Medical University, Fuzhou 350004, China

Abstract

In order to investigate the role of melatonin in inhibiting the proliferation of murine gastric cancer and the underlying molecular mechanism, we performed an in vivo study by inoculating murine foregastric carcinoma (MFC) cells in mice, and then tumor-bearing mice were treated with different concentrations of melatonin (i.p.). The changes of Bcl-2, Bax, p21 and p53 expressions in tumor tissue were detected by using real-time fluorescence quantitative RT-PCR and Western blot. We found that: (1) melatonin resulted in reductions of tumor's volume and weight in the gastric cancer-bearing mice and thus showed anti-cancer effect; (2) melatonin reduced Bcl-2 expression, but increased the expression of Bax, p53 and p21 in tumor tissue. Our results suggest that melatonin could inhibit the growth of tumors in gastric cancer-bearing mice through accelerating the apoptosis of tumor cells.

Key words: gastric cancer; melatonin; murine foregastric carcinoma; Bcl-2; Bax; p21; p53

Received: 2014-05-27　　Accepted: 2014-07-17

Corresponding author: 周瑞祥　　E-mail: zhourx@mail.fjmu.edu.cn

Citing This Article：

XU Li, JIN Qing-Dong, GONG Xi, LIU Hui, ZHOU Rui-Xiang. [Anti-gastric cancer effect of melatonin and Bcl-2, Bax, p21 and p53 expression changes.] [Article in Chinese]. Acta Physiol Sin 2014; 66 (6): 723-729 (in Chinese with English abstract).