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[MicroRNAs in microglia/macrophage polarization and CNS diseases: mechanism and functions.] [Article in Chinese]

FANG Xue, TAN Wei-Xing, HE Cheng, CAO Li^*

Department of Neurobiology, Second Military Medical University, Shanghai 200433, China

Abstract

Microglia are resident macrophages of central nervous system (CNS), and thus act as the crucial stuff of immune response and play very important roles in the progress of various CNS diseases. There are two different polarization statuses of activated microglia, M1 and M2 phenotypes. M1 polarized microglia are important for eradicating bacterial and promoting inflammation, whereas M2 cells are characterized by anti-inflammation and tissue remodeling. Recently, more and more evidence indicated that different polarized microglia showed diverse microRNA (miRNA) expression profiles. MiRNAs regulate microglia polarization, and thus affect the progress of CNS diseases. Fully exploring the polarization status of microglia during CNS diseases and the role of miRNAs in microglia polarization will be very helpful for a deep understanding of the roles of microglia in immunopathologic mechanism of different CNS diseases and offer the theoretical foundation of searching more effective therapies for these disorders.

Key words: miRNA; microglial/microphage; polarization; CNS disease;

Received: 2014-08-26　　Accepted: 2014-10-30

Corresponding author: 曹莉　　E-mail: caoli.smmu@gmail.com

Citing This Article：

FANG Xue, TAN Wei-Xing, HE Cheng, CAO Li. [MicroRNAs in microglia/macrophage polarization and CNS diseases: mechanism and functions.] [Article in Chinese]. Acta Physiol Sin 2015; 67 (1): 32-40 (in Chinese with English abstract).