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Progress of study on p62 and protein degradation pathways

LIU Shi-Meng, DONG Yue-Juan, Liu Bin

Institute of Neurobiology, College of Nursing； Department of Gastroenterology, Huaihe Clinical College, Henan University, Kaifeng 475000, China

Abstract

The p26, a multifunctional ubiquitin-binding protein, has been proposed to be involved in protein degradation as a component within the ubiquitin-proteasome and autophagy-lysosome systems. As a scaffolding protein with several different kinds of protein-protein interaction domains, p62 mediates various cellular functions. Importantly, p62 plays a critical role in cell’s selective autophagy and oxidative stress response, which are associated with the pathogenesis of several human diseases. In this review, we describe the structure of p62 and the mechanism of connection between p62 and ubiquitin-proteasome system/autophagy, so as to provide some perspectives on p62 research.

Key words: p62;protein degradation;ubiquitin;proteasome；autophagy ;

Received: 2014-05-22　　Accepted: 2014-07-29

Corresponding author: 刘彬　　E-mail: lbgood5912@sina.com

Citing This Article：

LIU Shi-Meng, DONG Yue-Juan, Liu Bin. Progress of study on p62 and protein degradation pathways. Acta Physiol Sin 2015; 67 (1): 45-58 (in Chinese with English abstract).