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[Progress on relationship between exercise improving insulin resistance and AMP-activated protein kinase.] [Article in Chinese]

LI Lei, LI Zhi-Jun

School of Physical Education, Huaibei Normal University, Huaibei 235000, China； Shanghai Research Institute Of Sports Science, Shanghai 200030, China

Abstract

The AMP-activated protein kinase (AMPK) widely exists in skeletal muscle, liver, pancreas, adipose tissue and central nervous system. As a "cellular energy regulator", activation of AMPK can improve insulin resistance in various mechanisms. To overall understand the importance of AMPK in exercise, the article summarized the research progress on AMPK exercise activation in skeletal muscle, liver and adipose tissue as well as exercise improving cardiovascular insulin resistance by AMPK, and looked forward to the study future of AMPK exercise activation.

Key words: AMP-activated protein kinase; insulin resistance; exercise

Received: 2013-07-25　　Accepted: 2013-11-06

Corresponding author: 李蕾　　E-mail: lisulei73@aliyun.com

Citing This Article：

LI Lei, LI Zhi-Jun. [Progress on relationship between exercise improving insulin resistance and AMP-activated protein kinase.] [Article in Chinese]. Acta Physiol Sin 2014; 66 (2): 231-240 (in Chinese with English abstract).