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[Progress in the role of farnesoid X receptor in metabolic regulation and tumor cell proliferation.] [Article in Chinese]

XIE Yang, ZHOU Xue-Yan, HAO Hai-Ping, WANG Guang-Ji^*

State Key Laboratory of Natural Medicines, Key Laboratory of Drug Metabolism &； Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, China

Abstract

Farnesoid X receptor (FXR) is a ligand-activated transcriptional factor belonged to the superfamily of nuclear receptors. In the past decades, FXR has been found with important roles in the regulation of metabolic homeostasis of bile acids, cholesterol, lipids and carbohydrates. Recent studies further demonstrate the potential protective effect of FXR against metabolic diseases, such as hyperglycemia and hyperlipidemia, as well as inflammatory bowel diseases (IBD). In addition, FXR plays an essential role in liver regeneration, tumor cell proliferation and apoptosis. However, the role of FXR in the development of tumor is still obscure and even with discrepancy. This article reviews the function of FXR in metabolic regulation and recent progress in basic, clinical and pharmacological researches related to tumor cell proliferation involving FXR.

Key words: farnesoid X receptor; metabolic regulation; tumor; proliferation

Received: 2013-08-30　　Accepted: 2013-10-08

Corresponding author: 王广基　　E-mail: guangjiwang@hotmail.com

Citing This Article：

XIE Yang, ZHOU Xue-Yan, HAO Hai-Ping, WANG Guang-Ji. [Progress in the role of farnesoid X receptor in metabolic regulation and tumor cell proliferation.] [Article in Chinese]. Acta Physiol Sin 2014; 66 (2): 252-258 (in Chinese with English abstract).