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Enhancement of polydatin on inward rectifier potassium channel current in rat ventricular myocytes

WEI Yan, ZHOU Jing-Jing, Yang Jing, ZHANG Jiao, ZHANG Li-Ping, Zhang Yi

Department of Physiology, Hebei Medical University, Shijiazhuang 050017, China； Department of Electrophysiology, Institute of Cardiovascular Research, Luzhou Medical College, Luzhou 646000, China； Hebei Key Laboratory of Medical Biotechnology, Shijiazhuang 050017, China

Abstract

The aim of this study was to investigate the effect of polydatin on transient outward potassium channel current (I_to), steady-state outward potassium channel current (I_ss) and inward rectifier potassium channel current (I_K1) in ventricular myocytes of rat using the whole-cell patch clamp technique. The results showed: (1) Polydatin (above 10 µmol/L) increased I_K1 of ventricular myocytes in a non-concentration dependent manner. (2) Polydatin neither had any effect on I_to peak current of ventricular myocytes, nor changed activation, inactivation and recovery kinetics of I_to. (3) Polydatin had no effect on I_ss of ventricular myocytes. These results suggest that polydatin enhances I_K1 channel activity, but has no effect on I_to and I_ss channels in rat ventricular myocytes, which might be one of the ionic mechanisms for antiarrhythmic effect of polydatin

Key words: polydatin; transient outward potassium channel; steady-state outward potassium channel; inward rectifier potassium channel; cardiomyocytes; rat

Received: 2012-09-13　　Accepted: 2013-01-08

Corresponding author: 张翼　　E-mail: zhyhenry@hotmail.com

Citing This Article：

WEI Yan, ZHOU Jing-Jing, Yang Jing, ZHANG Jiao, ZHANG Li-Ping, Zhang Yi. Enhancement of polydatin on inward rectifier potassium channel current in rat ventricular myocytes. Acta Physiol Sin 2013; 65 (3): 285-292 (in Chinese with English abstract).