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[Role of endogenous cannabinoid system in the gut.] [Article in Chinese]

LIN Xu-Hong, WANG Ya-Qiang, WANG Hui-Chao, REN Xue-Qun^*, LI Yong-Yu^*

Department of Pathophysiology, Institute of Digestive Disease, School of Medicine, Tongji University, Shanghai 200092, China； Department of Clinical Laboratory, Huaihe Hospital Affiliated to Henan University, Kaifeng 475000, China； Department of Nephrology, First Affiliated Hospital of Henan University, Kaifeng 475000, China； Department of General Surgery, Huaihe Hospital Affiliated to Henan University, Kaifeng 475000, China

Abstract

The plant Cannabis has been used in clinic for centuries, and has been known to be beneficial in a variety of gastrointestinal diseases, such as emesis, diarrhea, inflammatory bowel disease and intestinal pain. In this text, we'll review the components of the endogenous cannabinoid system as well as its role in the regulation of gastrointestinal activities, thus providing relative information for further study. Moreover, modulation of the endogenous cannabinoid system in gastrointestinal tract may provide a useful therapeutic target for gastrointestinal disorders.

Key words: cannabinoids; endogenous cannabinoid system; cannabinoid receptor; endogenous ligands; gastrointestinal function

Received: 2013-01-30　　Accepted: 2013-04-12

Corresponding author: 任学群,李永渝　　E-mail: hhyyrxq@126.com, liyongyu@tongji.edu.cn

Citing This Article：

LIN Xu-Hong, WANG Ya-Qiang, WANG Hui-Chao, REN Xue-Qun, LI Yong-Yu. [Role of endogenous cannabinoid system in the gut.] [Article in Chinese]. Acta Physiol Sin 2013; 65 (4): 451-460 (in Chinese with English abstract).