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[Roles of calcitonin gene-related peptide family in pain and opioid tolerance.] [Article in Chinese]

LIU Fang-Wei, HONG Yan-Guo^*

Laboratory of Neurological Biology, College of Life Science, Fujian Normal University, Fuzhou 350108, China

Abstract

The calcitonin gene-related peptide (CGRP) family mainly includes CGRPα, CGRPβ, adrenomedullin, calcitonin and amylin. The members of CGRP family and their receptors are widely distributed in the central and peripheral nervous systems. Studies show that members of CGRP family such as CGRP and adrenomedullin play important roles in the transmission of nociceptive information. At spinal level, CGRP promotes the transmission of nociceptive information, spinal morphine tolerance, migraine, inflammatory pain and neuropathic pain. At superspinal level, CGRP suppresses the transmission of nociceptive information. Adrenomedullin is a pain-related neuropeptide which has recently been demonstrated. It facilitates the transmission of nociceptive information and is involved in the development and maintenance of opioid tolerance. The involvement of amylin and calcitonin in pain is not clear yet.

Key words: Calcitonin gene-related peptide; adrenomedullin; pain; apioid tolerance

Received: 2012-10-18　　Accepted: 2012-12-11

Corresponding author: 洪炎国　　E-mail: yhong@fjnu.edu.cn

Citing This Article：

LIU Fang-Wei, HONG Yan-Guo. [Roles of calcitonin gene-related peptide family in pain and opioid tolerance.] [Article in Chinese]. Acta Physiol Sin 2013; 65 (3): 347-354 (in Chinese with English abstract).