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Effect of electrical stimulation of paraventricular nucleus on stress gastric mucosal lesion in rats

ZHANG Jian-Fu, ZHENG Fang, ZHAN Mao-Cheng, SUN Dong, YAN Chang-Dong

Department of Physiology, Xuzhou Medical College, Xuzhou 221002, China

Abstract

The effect of electrical stimulation of hypothalamic paraventricular nucleus (PVN) on gastric mucosal lesion induced by RWIS (restraint + water-immersion stress) in rats was investigated. The main results were as follows: (1) Electrical stimulation of the PVN could obviously increase the stress gastric mucosal lesion. (2) Microinjection of L-glutamate into PVN could produce similar effect to that of PVN stimulation. (3) PVN lesion could significantly decrease the stress gastric mucosal lesion. (4) The above mentioned effects were attenuated by vagotomy or atropine injected subcutaneously. (5) A further study indicated that the gastric mucosal blood flow was reduced upon PVN stimulation, but no obvious changes of gastric juice volume, total acid output, pepsin activity and gastric barrier mucus were observed. The results mentioned above indicate that the PVN is one of the specific CNS areas capable of increasing the stress-induced gastric mucosal lesion mediated through the cholinergic fibers of the vagal nerve and related to decreased gastric mucosal blood flow, while gastric acid output, pepsin activity and gastric barrier mucus do not seem to play any important role.

Key words: paraventricular nucleus (PVN); stress gastric mucocal lesion; gastric mucosal blood flow; rat

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Citing This Article：

ZHANG Jian-Fu, ZHENG Fang, ZHAN Mao-Cheng, SUN Dong, YAN Chang-Dong. Effect of electrical stimulation of paraventricular nucleus on stress gastric mucosal lesion in rats. Acta Physiol Sin 1992; 44 (6): 583-590 (in Chinese with English abstract).