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[Roles of cytokines in stress-induced depression.] [Article in Chinese]

Peng Yun-li, Wang Wen-ying, Jiang Chun-lei, Wang Yun-xia

Lab of Stress Medicine, the Second Military Medical University, Shanghai 200433, China； Department of Joint, Osteo-traumatic Hospital of Qingdao, Qingdao 266021, China

Abstract

Depression is a very common mental health problem in our modern society. Stress is involved in the provocation of depression. The pathogenesis of depressive disorder is still not well known. The development of neuroendocrine immunology opens a new sight for clarification of mechanism underlying stress-induced depression. Chronic stress activates peripheral and central immune systems accompanied with the release of inflammatory mediators, including cytokines. Activated immune system mediates the process of depression through the interaction with neuron system and neuroendocrine system, including regulating the monoamine neurotransmitter system in synthesis, metabolism and reuptake, inducing the overactivation of hypothalamus-pituitary-adrenal (HPA) axis and its negative feedback regulation, and reducing neurogenesis. This present paper reviews the cytokines mechanisms underlying stress-induced depression.

Key words: Stress; depression; cytokine; 5-HT; HPA axis; neural plasticity

Received: 2012-07-24　　Accepted: 2012-10-06

Corresponding author: 王云霞　　E-mail: cloudywang66@163.com

Citing This Article：

Peng Yun-li, Wang Wen-ying, Jiang Chun-lei, Wang Yun-xia. [Roles of cytokines in stress-induced depression.] [Article in Chinese]. Acta Physiol Sin 2013; 65 (2): 229-236 (in Chinese with English abstract).