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[Roles of phosphatidylethanolamine-binding protein in cell signaling and its biological functions.] [Article in Chinese]

BIAN Jia-ming, WU Ning, LI Jin

Department of Pharmacology, Military General Hospital of Beijing PLA, Beijing 100700, China； Institute of Toxicology and Pharmacology, Academy of Military Medical Sciences, Beijing 100850, China

Abstract

Phosphatidylethanolamine-binding protein (PEBP) is a cytoplasm soluble protein with a high conserved structure. It has been approved recently that PEBP is a multifunctional molecule regulating several important cellular signal pathways, including ERK cascade, NF-κB pathway, and signaling of G protein-coupled receptors. Furthermore, the role of PEBP in tumor metastasis also got a comprehensive attention in the field of clinical cancer research. Together, as a signal regulator at multiple paths in cell, PEBP is becoming a new focus in several research fields. This review is aimed to introduce the newest biological progress on PEBP.

Key words: phosphatidylethanolamine-binding protein; Raf kinase inhibitor protein; ERK; NF-κB; hippocampus

Received: 2012-08-15　　Accepted: 2012-11-09

Corresponding author: 李锦　　E-mail: jinli9802@163.com

Citing This Article：

BIAN Jia-ming, WU Ning, LI Jin. [Roles of phosphatidylethanolamine-binding protein in cell signaling and its biological functions.] [Article in Chinese]. Acta Physiol Sin 2013; 65 (2): 237-243 (in Chinese with English abstract).