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[Influence of prenatal alcohol exposure on retinal development and cell differentiation.] [Article in Chinese]

XI Yan, ZHOU Jie, KONG Wei-Fang, WANG Qiang, LIU Bin, ZHENG Hong, DENG Jin-Bo^*

Institute of Neurobiology, Henan University, Kaifeng 475004, China

Abstract

The aim of the present study was to investigate the effects of prenatal alcohol exposure (PAE) on the development and cell differentiation of retina in offspring. The mouse model of PAE was made. HE staining and immunofluorescent labeling were carried out to visualize the structure, development and cell differentiation of the retina from postnatal day 0 (P0)-P30 offspring. The results showed that PAE can lead to the retardation of retinal development, the reduction of number of bipolar cells and horizontal cells, the disorder of horizontal cells' polarity, as well as the retinal thickening in a dose-dependent manner. The data suggest that alcohol exposure during pregnancy can lead to the developmental retardation of retina and decreased number of bipolar cells and horizontal cells in the retina of offspring.

Key words: prenatal alcohol exposure; retinal development; horizontal cells; bipolar cells ;

Received: 2013-03-19　　Accepted: 2013-05-17

Corresponding author: 邓锦波　　E-mail: jinbo_deng@henu.edu.cn

Citing This Article：

XI Yan, ZHOU Jie, KONG Wei-Fang, WANG Qiang, LIU Bin, ZHENG Hong, DENG Jin-Bo. [Influence of prenatal alcohol exposure on retinal development and cell differentiation.] [Article in Chinese]. Acta Physiol Sin 2013; 65 (5): 505-512 (in Chinese with English abstract).