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[Biological function of Nogo-B.] [Article in Chinese]

XU Wu-Jian, SHEN Jian-Guo, LI Qiang

Department of Respiratory Disease, Changhai Hospital, Second Military Medical University, Shanghai 200433, China； China People’s Liberation Army 73676, Wuxi 214162, China

Abstract

Nogo-B is a major family member of the reticulon protein family 4. It is widely expressed in the central nervous system and peripheral tissues, and is mainly located in endoplasmic reticulum and cell membrane. Previous studies have revealed that Nogo-B plays a key role in vascular injury, tissue repair and inflammation process. It also may be critical for apoptosis of tumor cells and central diseases. Further investigation of the molecular characteristics and biological function of Nogo-B might be of great help to understand its role in diverse diseases.

Key words: Nogo-B; regeneration;Inflammation; apoptosis; Alzheimer's disease

Received: 2013-01-10　　Accepted: 2013-03-20

Corresponding author: 李强　　E-mail: liqressh@yahoo.com.cn

Citing This Article：

XU Wu-Jian, SHEN Jian-Guo, LI Qiang. [Biological function of Nogo-B.] [Article in Chinese]. Acta Physiol Sin 2013; 65 (4): 445-450 (in Chinese with English abstract).