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Lysophosphatidic acid receptors and the downstream signaling pathways in regulation of cardiac cell growth

Chen Xi

Cardiovascular Institute and Fu Wai Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College.Beijing 100037

Abstract

Lysophosphatidic acid （LPA） is a bioactive phospholipid messenger with multiple biological functions, including induction of neurite retraction, stress fiber formation, promotion of platelet aggregation and stimulation of smooth muscle contraction and cell proliferation. LPA exerts various biological functions through G protein-coupled receptors and the downstream cellular signaling pathways. LPA and its receptors may also play important roles in the heart since several LPA receptor subtypes exist in the heart and especially the level of LPAI subtype is the second highest, just lower than that in the brain. The review was focused on 5 subtypes of LPA receptor, mainly on their tissue expression pattern, coupled G proteins and signal pathways, as well as the roles of LPA and its receptors in regulation of cardiac cell growth.

Key words: lysophosphatidic acid receptors;Heart;Cell proliferation;Hypertrophy;Apoptosis

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Citing This Article：

Chen Xi. Lysophosphatidic acid receptors and the downstream signaling pathways in regulation of cardiac cell growth. Acta Physiol Sin 2007; 59 (5): 619-627 (in Chinese with English abstract).