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Epithelial ion channels in the regulation of female reproductive tract fluid microenvironment： implications in fertility and infertility

Chen Xiaozhang, He Qiong, Ajonuma L C, Wang Xiaofei

Epithelial Cell Biology Research Center, Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong.Hong Kong；China

Abstract

An optimal fluid microenvironment in the female reproductive tract is considered to be crucial for successtul reproducuve events. Fluid absorption and secretion across the reproductive tract epithelia largely depends on electrolyte transport through the apically and basolaterally located ion channels, working together with an array of other transporters. This review will discuss the role of epithelial sodium channel （ENaC） and the cystic fibrosis transmembrane conductance regulator （CFTR） in regulating the fluid volume and composition of the reproductive tract and their importance in various reproductive events such as sperm capacitation and implantation. Disturbance of the fluid microenvironment due to defects or abnormal regulation of these ion channels as causes for a number of pathological conditions, such as ovarian hyperstimulation syndromes, hydrosalpinx and infertility, is also discussed.

Key words: cystic fibrosis transmembrane conductance regulator;epithelial sodium channel;Epithelial cells;sperm capacitation;Implantation;infection

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Citing This Article：

Chen Xiaozhang, He Qiong, Ajonuma L C, Wang Xiaofei. Epithelial ion channels in the regulation of female reproductive tract fluid microenvironment： implications in fertility and infertility. Acta Physiol Sin 2007; 59 (4): 495-504 (in Chinese with English abstract).