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Regulation of pancreatic #beta#--cell function by adipocytes

Zhao Yufeng, Chen Chen

Endocrine Cell Biology, Prince Henry's Institute of Medical Research, Melbourne, VIC 3168

Abstract

Adipokines, the bioactive factors derived mainly from adipocytes, regulate pancreatic #beta#-cell function including insulin secretion, gene expression and apoptosis. In this review, we propose that adipokines influence #beta#-cell function through three inter-dependent pathways. The first is through regulating lipid and glucose metabolism in #beta#-cells. The second implicates the change of ion channel opening and closing in #beta#-cells. The third pathway is via the modification of insulin sensitivity of #beta#-cells. The endocrine function of adipocytes is dynamic, and the secretion of various adipokines changes under different metabolic conditions. During the progression from the normal state to obesity and to type 2 diabetes, adipokines contribute to the occurrence and development of #beta#-cell dysfunction in type 2 diabetes.

Key words: adipokines;Insulin;#beta#-cells;Diabetes

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Citing This Article：

Zhao Yufeng, Chen Chen. Regulation of pancreatic #beta#--cell function by adipocytes. Acta Physiol Sin 2007; 59 (3): 247-252 (in Chinese with English abstract).