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H_(2)S and cellular proliferation and apoptosis

Yang Guangdong, Wang Rui

Medical Research Centre, Lakehead University, Ontario P7B 5E1

Abstract

Hydrogen sulfide (H_(2)S) is among a family of endogenous molecules of gas, defined as gasotransmitters. In recent years,endogenous production of H_(2)S and its physiological importance have been realized. Abnormal metabolism and functions of H_(2)S contribute to or participate in the pathogenesis of many diseases. This article reviews recent discoveries on the roles of H_(2)S in the regulation of cell proliferation and apoptosis. The molecular mechanisms for the cellular effects of H_(2)S are also recapitulated, including changes in mitogen-activated protein kinase, cell cycle-related kinase, cell death-related gene and ion channels. A better understanding of H_(2)S-regualted cell growth or death will pave way for future design of novel pharmacological and therapeutic interventions for various diseases.

Key words: H_(2)S;gasotransmitter;cystathionine #gamma#-lyase;Proliferation;Apoptosis

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Citing This Article：

Yang Guangdong, Wang Rui. H_(2)S and cellular proliferation and apoptosis. Acta Physiol Sin 2007; 59 (2): 133-140 (in Chinese with English abstract).