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Detection of serum autoantibodies against AT_(1A)--receptor during the development of the four types of hypertensive rat models

Chen Rongfang, Wang Jin, Jiao Xiangying, Liu Huirong, Zhao Rongrui, Zhi Jianming

Department of Toxicology, the Second Military Medical University. Shanghai 200433, China；Department of Physiology, Shanxi Medical University. Taiyuan 030001, China；Department of Physiology, School of Medical Sciences, Shanghai Jiaotong University. Shanghai 200025, China

Abstract

Using two-kidney one-clip renal hypertensive (2K1C group), stress-induced hypertensive (neural group), DOCA-salt treated hypertensive (DOCA group) and spontaneously hypertensive rats (SHR group), to investigate the change in AT_(1A)-receptor autoantibodies (AT_(1A)-AAs) during the development of the four types of hypertension. The biological activities of AT_(1A)-AAs were examined. It was shown that the frequency of occurrence and titres of AT_(1A)-AAs increased significantly during the development of hypertension. In the four hypertensive groups studied, the occurrence of AT_(1A)-AAs was most prominent in SHR, 2K1C and neural groups. The biological effects of AT_(1A)-AAs were shown to increase the beating frequency of cultured neonatal myocardial and vascular contractile tension. It is suggested that autoimmune mechanisms are involved the pathogenesis of different types of hypertension and the AT_(1A)-AAs may be one of the mechanisms leading to cardiac hypertrophy.

Key words: Receptor, angiotensin, type 1;Autoantibody;;

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Citing This Article：

Chen Rongfang, Wang Jin, Jiao Xiangying, Liu Huirong, Zhao Rongrui, Zhi Jianming. Detection of serum autoantibodies against AT_(1A)--receptor during the development of the four types of hypertensive rat models. Acta Physiol Sin 2006; 58 (1): (in Chinese with English abstract).