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Role of the central interleukin-1 in stress responses

Zheng Ruimao, Zhu Shigong

Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University. Beijing 100083, China；2Laboratory for Higher Brain Functions, State Key Laboratory of Brain and Cognitive Science, Institute of Psychology, Chinese Academy of Sciences. Beijing 100101, China

Abstract

The molecules of interleukin-1 (IL-1) system are widely distributed in central nervous system. As a classical pro-inflammatory factor, central IL-1 has diverse biological functions and plays a pivotal role in a number of important physiological and pathophysiological processes. During the past few years, particular attentions have been directed to the stress mediator actions of central IL-1. This paper reviews some recent findings in the studies of central IL-1 functions in stress responses, including the effects of stress on central IL-1, the roles of IL-1 in the initiation of stress responses, the neural circuitries and intracellular signal transduction pathways involved in the central IL-1 mediated stress responses, as well as the actions of central IL-1 on brain high function and behavior under stressful conditions.

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Citing This Article：

Zheng Ruimao, Zhu Shigong. Role of the central interleukin-1 in stress responses. Acta Physiol Sin 2005; 57 (4): (in Chinese with English abstract).