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Abstract

Using nystatin-perforated whole-cell recording configuration, the modulatory effect of serotonin (5-hydroxytryptamine, 5-HT) on taurine (Tau)-actovated current (ITau) was investigated in neurons dissociated from the rat sacral dorsal commissural nucleus (SDCN). The results are as follows: (1)Tau acted on strychnine-sensitive glycine glycine (Gly)receptors and elicited inward currents at a holding potential (VH) of-40 mV in SDCN neurons; (2) in a range of 0.01 to 100 μmol/L, 5-HT enhanced ITau. in a concentration dependent manner; (3) both the reversal potential of Tau and the binding affinity of Tau to Gly receptor were not affected by 5-HT; (4) when the neurons were loaded with 3 μmol/L chelerythrine, application of 1 μmol/L 5-HT failed to enhance ITau. The above results thus indicate that intracellular PKC pathway is at least partially involved in the enhancement of ITau by 5-HT.

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Citing This Article：

, , , . . Acta Physiol Sin 1998; 50 (6): (in Chinese with English abstract).