Abstract
The effects of Zn2+ on GABAA-receptor mediated responses in acutely isolated rat sacral dorsal commissural nucleus (SDCN) were studied using nystatin-perforated whole cell rechniques .The results demonstrated that (1) GABA induced inward currents through activation of GABAA~at a holding potential of-40 mV; (2) GABAA-receptor mediated responses were suppressed by Zn2+ in a reversible and voltage-independent manner; and (3) in the presence of Zn2+, the concentration-response curve of CABA-induced responses was shifted to the right in a parallel manner. The results suggest that Zn2+allosterically depresses GABAA-receptor mediated currents.
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Citing This Article：
, , , . . Acta Physiol Sin 1998; 50 (6): (in Chinese with English abstract).
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