Abstract
To observe the effect of intracarotid administraation of adenosine on neurons in the rostral ventrolateral medulla (RVLM) region, 72 spontaneous active units were extracellulary recorded from 28 Sprague-Dawley rats with sino-aortic denervation. The results obtained are as follows: (1) intracarotidadministration of Ado (25 μg/kg) reduced the discharge rate from (23 .5 ± 3.0) to (16.5± 2.6) spikes/s (P< 0.001) in 31 out of 36 RVLM neurons, while the blood pressure and heart rate had no significant change (P > 0.05); (2) 8-phenyltheohylline (8-PT, 15 μg/kg), a nonselective adenosine receptor antagonist, and 8-cyclopentyl-1,3-dipropylxanthinee (DPCP, 50 μg/kg), a selective A1 adenosine receptor antagonist,completely blocked the inhibitory effects of Ado in 24 units; and (3) in 12 units, glibenclamide (500) μg/kg), a blocker of ATP-sensitive potassium channel, abolished the effect of Ado.
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Citing This Article：
, . . Acta Physiol Sin 1998; 50 (6): (in Chinese with English abstract).
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