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Abstract

In the present stUdy, the relationship between the blockade Of K-opioid receptor and ischemic preconditioning (IP) was examined and the effect of lP and prolonged ischemia on levels of dynorphin A1-13 (Dyn A1-13) in cardiac muscle in isolated perfused rat heart was investigated. The results are as follows: (1) IP reduced the severity of ischemia/reperfusion arrhythmia (P < 0.05) and infaret size (P < 0.01 ), but had no significant effect on heart rate and coronary flow (p > 0.05); (2) MR2266, K opioid receptor antagonist, reduced the severity of ischemia/reperfusion arrhythmia(P < 0.05)and infarct size (P < 0.01 ), and also enhanced the recovery of coronary flow, but had no significant effect on heart rate (P > 0.05); and (3) prolonged ischemia decreased the levels of Dyn A1-13 (P < 0.05), which was more marked in the unpreconditioned hearts. The results suggest: (1 ) MR2266 can "mimic" cardioprotective effect of IP in reducing the severity of arrhythmias and limiting infarct size of cardiac muscle.

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Citing This Article：

, , , . . Acta Physiol Sin 1998; 50 (6): (in Chinese with English abstract).