Abstract
Vestibular compensation is the most extensively investigated model forneuroplasticity. Growth-associated protein (GAP-43) mRNA plays a significant role innerve regeneration and synaptic remodeling. Using in situ hybridization with DIG(digoxigenin)-labeled GAP-43 cDNA probe, changes of GAP-43 mRNA expression inthe medial vestibular nucleus in the labyrintheectomized rats at 5, 12, 20 and 30th dayafter operation were investigated. The results clearly demonstrated that labyrinthectomyincreased GAP-43 mRNA expression to different extents and amplitudes in bilateral medialvestibular nuclei. This finding suggests that upregulation of GAP-43 mRNA expression isrelated tO regenerative sprouting, synaptic remodeling and neuroplasticity in vestibularcompensation.
Received: Accepted:
Corresponding author: E-mail:
Citing This Article：
, , , . . Acta Physiol Sin 1998; 50 (5): (in Chinese with English abstract).
Copyright © 1927-2022 Acta Physiologica Sinica All Rights Reserved
Address: Room 405, Building 31B, 319 Yueyang Road, Shanghai 200031, China Tel: +86-21-54922832 E-mail: actaps@sinh.ac.cn
沪ICP备05033115号-81
