Abstract
The effect of glucocorticoid on the increase of cytosolic free calcium [ Ca2+ j, )induced by high-K+ was investigated in pheochomocytoma PC12 cells. The aden restiltwas as follows: (l ) When the cells were preincubated at 37t for various time intervallin the presence of 10-5 moVL of corticosterone and stimulated with 55 mrnol/L KCI, anichbitory effect of conicosterone on b [ CaZ + ]. was observed in a bine-dependent mannerwith ~rnal effect at sib adn and no effect at 25th adn. (2) adn PC12 cells werepreincubated with various concentration of corticosterone at 37T for 5 adn, the inhibitoryeffect of corticosterone on A [ Ca2+ ]. induced by 55 rnmol/L KCI was concentrationdependent. The effect was found to be maximal at 10--5 moVL of colticosternne anddiSappeared at 10-9 moUL of corticosterone.
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Citing This Article：
, , , . . Acta Physiol Sin 1998; 50 (5): (in Chinese with English abstract).
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