ISSN 0371-0874, CN 31-1352/Q

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Abstract

Mitogen-activated protein kinases (MAPKs) are thought to be critical components insignal transduction pathways in regulation of cell growth and differentiation. The purposeof the present investigation is to study possible involvement of MAPKs in the progress ofcardiac hypertrophy in spontaneously hypertensive rats (SHRs) and effects of age onAngiotensin Ⅱ (Ang Ⅱ), MAPK activity and cardiac hypertrophy. The animals weredivided into thee groups: 4 months old WKY rats (n=8), 4 month old SHRs (n=8)and 15 month old SHRs (n=6). Ratio of heart to body weight was measured. Ang Ⅱwas determined by RIA. MAPK activity in cardiac tissue was assayed by the "in-gel"myelin basic protein phosphorylation. The results show that in comparison with 4 monthold WKY rats, Ang Ⅱ in plasma and cardiac tissues were elevated (216.4%, P<0.01; 101.2%, P < 0.01 ) in 4 months old SHRs, while the MAPK activity wasincreased 107.0% (P < 0.01 ) with a parallel cardiac hypertrophy (P<0.01).

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, , , , , . . Acta Physiol Sin 1998; 50 (5): (in Chinese with English abstract).