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Cui Hong

First Clinical Institute，China Medical University. Shenyang 110001,Liaoning, China

Abstract

It has been previously shown that the activation of A1 adenosine receptors in frogmelanotroph induced a hyperpolarization accompanied by blockage of spontaneous actionpotentials. In the present report, we explored mechanisms underlying the abovephenomenon using the pacth-clamp technique in whole-cell and cell-attachedconfigUration. The result showed that adenosine could increase the opening of nonvoltage-activated potassium channels leading to hyperpolarization, but an inward cationcurrent activated by hyperpolarizing pulse was not involved.

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Citing This Article：

Cui Hong. . Acta Physiol Sin 1998; 50 (5): (in Chinese with English abstract).