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Cui Hong

First Clinical Institute，China Medical University. Shenyang 110001,Liaoning, China

Abstract

The effect of α- melanocyte-sitmulating hormone (α-MSH ) on IL-1βinduced feverand release of hypothalaminc cAMP was observed in the present work. The results showedthat α-MSH markedly suppressed febrile response (P<0.05) and decreased the cAMPcontent in hgpothalamus in response to icy injection of IL-1β (P<0.01).The cAMPcontent of the medium in which the hypothalamic was incubated for 40 min in thepresence of IL-1βwas significantly increased (P<0.01). However, this increase actioncould be prevented by a pretreatment with α-MSH. The results indicate that the inhibitoryeffect of α-MSH on the enhanced synthesis and release of cAMP in hypothalamus exposedto IL-1β mingt be one of the mechanisms of suppressing fever induced by IL-1β.

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Citing This Article：

Cui Hong. . Acta Physiol Sin 1998; 50 (5): (in Chinese with English abstract).