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Cui Hong

First Clinical Institute，China Medical University. Shenyang 110001,Liaoning, China

Abstract

Extracellular single-unit discharges were obtained from 106 spontaneously active neurons inthe region of the rostral ventrolateral medulla (RVLM) by glass microelectrode from 73 brain slices of SpragueDawley rats. Exogenous γ-aminobutyric acid (GABA, 0. 1 ~3.0 mmol/L) inhibited the electrical activity of84 out of 106 RVLM neurons dose-dependently. The inhibitory effect of GABA could be blocked by GABAAreceptor antagonist bicuculline bicuculline methiodide (BMI) and Cl- channel blocker picrotokin (PTX). When perfusedwith BMI or PTX alone, the firing rates of most of the RVLM neurons were significantly increased. In 41neurons responding to GABA, baclofen (0. 1 ~ 3.0 μmol/L), a GABAB receptor selective agonist, inhibitedthe discharges of 33 of the neurons dose-dependently. GABAB receptor antagonist CGP35348 (n = 13) blockedthe inhibition due to baclofen (n = 21 ). After perfused with CGP35348 alone, the firing rates of most of theRVLM neurons were significantly increased.

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Citing This Article：

Cui Hong. . Acta Physiol Sin 1998; 50 (5): (in Chinese with English abstract).