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Cui Hong

First Clinical Institute，China Medical University. Shenyang 110001,Liaoning, China

Abstract

The effect of ACTH4-9 analogue Org2766 on the [Ca2+], level of mouse hippocampal synaptoSomes was studied. Synaptosomal free calcium concentration ([Ca2+]i) and 45Ca2+ uptake were measured respectively by spex cation measurement system and Beckman LS-9800 liquid scintillation spectrometer. Low dose of Org2766 did not change synaptosomal [Ca2+]i level, but decreased 45Ca2+ uptake. High dose of Org2766increased [ Ca2+ ], without affecting 45Ca2+ uptake. Lom dose of Org2766 inhibited the anisomysin-induced increase of synaptosomal [ Ca2+ ]. while high dose had no effect.These results suggest that the regulation of Org2766 on hippocampal synaptosomal Ca2+level may be achieved by inhibiting the Ca2+ influx and increasing the release of synaptosomal calcium pool.

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Citing This Article：

Cui Hong. . Acta Physiol Sin 1998; 50 (4): (in Chinese with English abstract).