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Cui Hong

First Clinical Institute，China Medical University. Shenyang 110001,Liaoning, China

Abstract

Migrating motor complex (MMC) was recorded by chronically implanted strain gauge transducers on the serosa of small bowel in conscious dogs. Two silastic catheters for injecting ho and taking blood samples were put respectively in a vena jugularis externa and in a jejunal artery which perfused a 10 ~ 15 cm intestinal segment. The present study was undertaken to observe the effect of drugs administered intravenously and intraarterially on MMC and alterations of plasma 5-hydroxytryptamine(5-HT) and motilin in different phases of MMC. The results showed: (1) Levels of plasma 5-HT and motilin showed cyclical fluctuations in different phases of MMC, and 5-HT reached peak before peak of motilin. Plasma 5-HT level reached a peak [(41.2±1 .3) ng/ml] in the later pened of phase Ⅱ, which increased significantly as compared with phase Ⅰ [ (22.4±1.1 )ng/ml (P < 0.01 ), but plasma motilin level had a peak [ (580.0 ± 30.2) pg/ml]in phaseⅢ of MMC, which was higher than that in phase 1 [ (140.0±21 .0) pg/ml](P < 0.01 ).

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Citing This Article：

Cui Hong. . Acta Physiol Sin 1998; 50 (4): (in Chinese with English abstract).