Issue Archive

Cui Hong

First Clinical Institute，China Medical University. Shenyang 110001,Liaoning, China

Abstract

In the present paper, the modulation of GABA-activited currents by bradykinin (BK) was studied in DRG neurons freshly isolated from rat using whole－cell patch clamp techniques. Among the neurons (n=34)responding to GABA，27 were sensitive to BK．Pre－application of BK，eliciting an inward current alone, inhibited GABA-activated current markedly．For example, 10-6 mol/L BK suppressed GABAactivated current by aboot 30%．BK shifted the GABA dose-response curve downward obviously and depressed the maximal response to GABA by 1/3 or more while the Kd value was unchanged. The results suggest that BK inhibits GABA-activated current noncompetitively in rat DRG neurons.

Key words: ;;;

Received: 　　Accepted:

Corresponding author: 　　E-mail:

Citing This Article：

Cui Hong. . Acta Physiol Sin 1998; 50 (4): (in Chinese with English abstract).