Cui Hong
First Clinical Institute,China Medical University. Shenyang 110001,Liaoning, China
Abstract
In the present work, the effects of tachykinin receptor antagonists on formalininduced c-fos expression in the rat spinal cord were studied by a combination of immunocytochemical and neuropharmacological methods. Formalin injected into a hindpaw of rat only resulted in c-fos expression in the ipsilateral dorsal horn neurons of the spinal cord. Fos-positive neurons were distributed mainly in medial parts of the lamina Ⅰand the outer lamina Ⅱ. A moderate number of Fos-positive neurons were present in laminae Ⅳ-Ⅴ, and a few in the inner lamina Ⅱand in laminae Ⅲ, Ⅵ and X.Selective NK-1 antagonist L-668, 169 (0.1, 1 and 10μg) administered intrathecally before injection of formalin into a hindpaw significantly reduced the number of Fos-labeled neurons in the dorsal horn in a dose-dependent manner (P < 0.01), while selective NK-2 antagonist L-659, 877 (10μg) and selective NK-3 antagnnist SR-142, 801 (10μg)were ineffective (P> 0.05).
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Citing This Article:
Cui Hong. . Acta Physiol Sin 1998; 50 (4): (in Chinese with English abstract).