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Cui Hong

First Clinical Institute，China Medical University. Shenyang 110001,Liaoning, China

Abstract

In our previous electrophysiological study, it was shown that N'MDA receptors are predodrinately involved in the transmission of nociceptive cutaneous afferents, whereas non-N'MDA receptors are mainly concerned with the transmission of nociceptive muscular afferents. In the present investigation, the effects of NMDA and non-N'MDA receptor antagonists were tested in rat hindpaw withdraWal resPOnse to noxious thermal shmulation. Ihtrathecal application of non-NMDA receptor antagonist 1 runoUL DNQX (6, 7dinimpinoxaline-2, 3 (IH, 4H)-dione ) had no effect on paw withdrawal latencies(PWL ), but NMDA receptor antagonist I runoUL APV [(l ) 2-piano-5phosphonovalerate) ] significantly prolonged Pad (P < 0.05). Both APV and DNQX at10 nmoUL significantly increased PWL with the former agent being more potent.

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Citing This Article：

Cui Hong. . Acta Physiol Sin 1998; 50 (3): (in Chinese with English abstract).