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Cui Hong

First Clinical Institute，China Medical University. Shenyang 110001,Liaoning, China

Abstract

The effects of endothelin-1 (ET-1 ) at physiological level on the secretion of pulmonmp surfactant (PS) were studied on isolated nonperfused rat lungs. The results showed that ET-1 (10-12 and 10-10 mol/L) increased the hasal secretion of total phospholipids (TP) and phosphatidylcholine (PC), and potentiated the stimulatory effect of intendttent lung inflation on the secretion of ac and PC. The effect of ET-l could be inhibited by H7, a protein kinase C (PKC) inhihitor. When the cultured lung tissue was exposed respectively to ET-1 (10-12 and 10-10 mol/L) for I h and 4 h,the content of ET in the lung tissue increased significantly. These results suggest that ET-l at the physiological concentration is involved in modulating PS secretion thlough a PKCdependent pathway, and can also promote ET production in lungs.

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Citing This Article：

Cui Hong. . Acta Physiol Sin 1998; 50 (3): (in Chinese with English abstract).