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Cui Hong

First Clinical Institute，China Medical University. Shenyang 110001,Liaoning, China

Abstract

Experiments were Performed on neurons freshly isolated from rat DRG using wholecell patch-clamp techniqUes. The majority of the neurons examined were sensitive to GABA (60/70) in the concentration range from 10-6 to 10-3 mol/L, showing obvious desensihzation. In the 60 GABA-sensitive cells, responses induced by selective agonist Of dopamine D1 receptor Sin8393 [ (±) SKF38393HCL] manifested three types: (1)outward current (7/60); (2) inward current (5/60) and (3) no detectable response (48/60). As compared with GABA-activated current, the amplitude of SKF38393activated current are smaller and showed no apparent desensitization. When the neurons were treated with SKF38393 prior to application of GABA for 30 s, the GABA-activated current in majority of the cells (53/60) was inhibited, while the remaining six showed no effect. The effect of Sin8393 was dose dependent.

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Citing This Article：

Cui Hong. . Acta Physiol Sin 1998; 50 (3): (in Chinese with English abstract).