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Cui Hong

First Clinical Institute，China Medical University. Shenyang 110001,Liaoning, China

Abstract

Employing imrnunohistochendcal staining for FOS protein, which is the eXpression product of c-fos proto-oncogene, the role of substance P receptor (SPR) in noxious information transgression at peripheral terminals of the dorsal root ganglion cells was investigated by means of a selective SPR antagonist In68, 169 and agonist Sar-SP.Unilateral injection of to68, 169 (10-4 mo;/L) into the plantal of hindpaw 10 min before injection of 4% formalin, the number of FOS-like immunoreactive (LI) neurons in the superficial ldrinae of dosal horn was significantly decreased, but the changes were not obvious in the deeper laminae. Smaller doses of L668, 169 (10-5, 10-6 mol/L) were almost ineffective on FOS-LI neurons in both the superficial and the deeper laminae.However, Sar-SP (10-4 mol/L) or formalin did result in the expression of c-fos gene in the superficial laminae of the dosal horn.

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Citing This Article：

Cui Hong. . Acta Physiol Sin 1998; 50 (3): (in Chinese with English abstract).