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Cui Hong

First Clinical Institute，China Medical University. Shenyang 110001,Liaoning, China

Abstract

Orphanin Fo (OFQ) is a newly-discovered neuropeptide which shares great simliar sequence with endogenous opioid peptide but with different functions. The present study was to investigate the role of OFQ dricroinjected in the periaqueductal gray (PAG) on pain threshold and acupuncture analgesia (AA) using tail flick tests. The results show that the hyperalgesia of OFQ and its antagonization on AA in PAG are dose-related. OFQ in PAG decreases the enhancing effect on AA induced by ohlnefentanyl, a selective μreceptor agonist. These observations suggest that OFQ in PAG can increase the rat pain sensitivity and antagonize AA.

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Citing This Article：

Cui Hong. . Acta Physiol Sin 1998; 50 (3): (in Chinese with English abstract).