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Effects of noradrenaline on delayed outward potassium current in isolated rat hepatocytes

Cui Guiping, La Jinming, Liu Dongju, Cui Hong

Department of Phaamacology, China Medical University. Shenyang 110001,Liaoning, China；First Clinical Institute，China Medical University. Shenyang 110001,Liaoning, China

Abstract

Heretofore no reports are available on the outward potassium currents in rat hepatocytes.Using whole-cell patch clamp tecboque, the effects of noradrenaline and other reagents on the delayed outward potassium current (I_(K)) in isolated rat hepatocytes were investigated. The experimental results showed that the magnitude of I_(K) was 2.85±1.21 nA at a command potential of+140 mV from a holding potential of-50 mV.Noradrenaline decreased I_(K) distincily. Isoprenaline and acetylcholine showed no effect on I_(K) in isolated rat hepatocytes.

Key words: Delayed outward potassium current;Patch clamp method;Noradrenaline;Hepatocyte

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Citing This Article：

Cui Guiping, La Jinming, Liu Dongju, Cui Hong. Effects of noradrenaline on delayed outward potassium current in isolated rat hepatocytes. Acta Physiol Sin 1998; 50 (2): (in Chinese with English abstract).