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Modulatory action of a2-adrenoceptor on calcitonin gene-related peptide release from rat mesenteric arterial bed

Sun Wei, Han Qide, Tang Yueming, Wang Man

Institute of Vascular Medicine，Third Hospital，Beijing Medical University. Beijing 100083,China

Abstract

The release of calcitonin gene-related peptide (CGRP) from peripheral terminals of sensory nerves was modulated via multiple mechanisms. In the present study, pharmaological agents were used to investigate the modulatory action of #alpha#_(2)-adrenoceptor on endotoxin-induced CGRP release from isolated perfused rat mesenteric arterial bed.The results showed that UK14300 (3×10~(-6) mol/L), a potent #alpha#_(2)-adrenoceptor agonist,significantly inhibited both basal and endotoxin-induced CGRP release by 22%-42% ,while specific antagonist of #alpha#_(2)-adrenoceptor yohimbine (10~(-5) mol/L) blocked the effect of UK14304 completely. The data suggest that presrpaptic #alpha#_(2)-adrenoceptor has an inhibitory effect on basal and endotoxin-induced CGRP release. Dysfunction of #alpha#_(2)-adrenoceptor in the late stage of endotoxic shock may be involved in the excess release of CGRP from the peripheral nerves.

Key words: Calcitonin gene-related peptide;#alpha#_(2)-adrenoceptor;Endotoxin

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Citing This Article：

Sun Wei, Han Qide, Tang Yueming, Wang Man. Modulatory action of a2-adrenoceptor on calcitonin gene-related peptide release from rat mesenteric arterial bed. Acta Physiol Sin 1998; 50 (2): (in Chinese with English abstract).