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Modulatory effects of endotiielin on carotid baroreflex in anesthetized rats

Li Depei, Fan Zhenzhong, He Ruibong

Depaatment of Physiology，Institute of Basic Medicine，Hebei Medical University. Shtjiazhuang 050017,China

Abstract

Modulatory effects of endothelin (ET) on carotid harorellex were examined in 27 anesthetized rats With isolated carotid sinus perfusion. The results obtained were as follows: (1) By perfusing with 1 nmol/L ET-1, the functional curve of carotid baroreflex (FCCB) was shifted to the left and downward with an increase in its peak slope (PS)from 0.40±0.02 to 0.51±0.02 kPa/kPa (P<0.01), while the reflex decrease of mean arterial pressure (RD) was increased from 5. 66±0. 23 to 6.76±0.22 kPa (P<0.01). The above results indicated that this dose of ET-1 facilitated the carotid baroreflex. (2) On the contrary, by perfusing with 10 nmol/L of ET-1, FCCB was shifted to the right and upward with a dearease of PS to 0.28±0.01 kPa/kPa (P<0.01), while RD was decreased to 4. 16±0. 19 kPa (P<0.01). In response to perfusion with 100 nmol/L ET-1,FCCB was further shifted to the right and upward with a marked decrease of PS to 0.19±0.03 kPa/kPa(P<0.001), and RD was conspicuously decreased to 3.33±0.38 kPa (P< 0.001).

Key words: Endothelin-1;Baroreflex;Mean arterial pressure;Intrasinus pressure

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Citing This Article：

Li Depei, Fan Zhenzhong, He Ruibong. Modulatory effects of endotiielin on carotid baroreflex in anesthetized rats. Acta Physiol Sin 1998; 50 (2): (in Chinese with English abstract).