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Expression of opioid-receptor-like receptor [ORL_(I)]gene in rat brain

Yang Ru, Lu Shiduo, Zheng Ziienlin, Zhao Jing, Zhang Xianning, Chen Li, Pei Gang, Ma Lan

National Laboratory of Medical Neurobiology, Shanghai Medical University. Shanghai 200032,China；Institute of Cell Biology，Chinese Academy of Sciences. Shanghai 200031,China

Abstract

In situ hybridization with a digoxigenin-labeled oligonucleotide probe was used to investigate the expression of opioid-receptor-like receptor [ORL_(1)] gene in rat brain. It was observed that ORL_(1) mRNA is widely expressed in many regions of rat brain,particulary in cerehral cortex, thamalus, hypothamalus, amygdala, hippocampus,septum, habenula, periaqueducted gray, raphe nuclei and locus coeruleus structure.These findings suggest tha ORL_(1) receptor may participate in modulating a number of physiological functions in the brain in addition to pain.

Key words: Opioid receptor-like receptor[ORL_(1)];Rat brain;In situ hybridization

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Citing This Article：

Yang Ru, Lu Shiduo, Zheng Ziienlin, Zhao Jing, Zhang Xianning, Chen Li, Pei Gang, Ma Lan. Expression of opioid-receptor-like receptor [ORL_(I)]gene in rat brain. Acta Physiol Sin 1998; 50 (2): (in Chinese with English abstract).